By L. Robert, T. Fulop, T. Fulop
Getting older encouraged loads of theories attempting to rationalize the getting older technique universal to all residing beings. during this ebook an important environmental and intrinsic mechanisms fascinated with the getting older method and in its pathological effects are reviewed. additionally theoretical and experimental facts of an important theoretical parts in accordance with Darwinian evolution, mobile getting older, function of telephone membranes, loose radicals and oxidative methods, receptor-mediated reactions, the extracellular matrix and immune services in addition to crucial environmental and intrinsic mechanisms desirous about the getting older procedure and in its pathological outcomes are mentioned. those shows of theories and comparable experimental proof supply an international evaluation of contemporary suggestions of the biology of the getting older technique and are of crucial analyzing not just for experts during this box but in addition for practitioners of medical, scientific, social and experimental sciences.
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Nature 1976;260: 523– 525. 20 Le Bourg E: Predicting whether dietary restriction would increase longevity in species not tested so far. Ageing Res Rev 2010;9:289–297. 21 Medawar PB: An Unsolved Problem in Biology. London, HK Lewis, 1952. 22 Williams GC: Pleiotropy, natural selection, and the evolution of senescence. Evolution 1957;11:398–411. 23 Kirkwood TBL: Understanding ageing from an evolutionary perspective. J Intern Med 2008; 263: 117– 127. 24 Austad SN: Why We Age. New York, John Wiley and Sons, 1997.
48 Rusted JM, Evans SL, King SL, Dowell N, Tabet N, Tofts PS: APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures. Neuroimage 2013; 65: 364–373. 49 Giaimo S, d’Adda di Fagagna F: Is cellular senescence an example of antagonistic pleiotropy? Aging Cell 2012; 11:378–383. 50 Maison P, Balkau B, Simon D, Chanson P, Rosselin G, Eschwège E: Growth hormone as a risk for premature mortality in healthy subjects: data from the Paris prospective study.
Radiation-induced senescence-like growth arrest is independent of telomere shortening . No signiﬁcant  or only a slight telomere shortening  was observed in senescence-like induced growth arrest of human ﬁbroblasts after hydrogen peroxide stress. Telomere biology seems to vary with the species in a way unrelated with aging and with the respective cell proliferation life span in vitro. In non-human primates such as rhesus monkey, Japanese monkey, crab-eating monkey, chimpanzee, and orangutan, TRF length was more than double that of human somatic tissues .