By Wojciech Gorczyca
This Atlas is a vital advisor to either the analysis and differential prognosis of neoplastic hematopathologies, in keeping with particular parameters. it will likely be a useful reference for all training hematologists, oncologists and pathologists. Atlas of Differential prognosis in Neoplastic Hematopathology, moment variation discusses: easy medical facts prognostic info morphologic info phenotypic info together with over six hundred colour illustrations, Atlas of Differential prognosis in Neoplastic Hematopathology, moment variation is generally referenced and up-to-date. overlaying neoplastic hematopathology, with an emphasis at the differential prognosis, various tables summarize the phenotypic profiles of the most typical hematologic tumors, for the training hematologist, oncologist and pathologist. NEW TO the second one version: A multimethodologic method of neoplastic hematopathology New and considerably up-to-date sections on differential analysis and morphology, chromosomal and genetic alterations, and localization
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Extra info for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
Production of blood cells (hematopoiesis). Hematopoiesis is the process in which early progenitor cells progressively differentiate into intermediate and mature elements. g. ). Bone marrow contains progenitor cells called stem cells. Stem cells have the pluripotent capacity for both self renewal and differentiation. These cells give rise to all the different cell series of lymphocytes, and myeloid cells. The myeloid lineage is comprised of all non-lymphoid white cells, red cells, and platelets.
G) Rosai–Dorfman disease. (H) Histiocytic sarcoma. production of blood cells (hematopoiesis). Hematopoiesis is the process in which early progenitor cells progressively differentiate into intermediate and mature elements. g. ). Bone marrow contains progenitor cells called stem cells. Stem cells have the pluripotent capacity for both self renewal and differentiation. These cells give rise to all the different cell series of lymphocytes, and myeloid cells. The myeloid lineage is comprised of all non-lymphoid white cells, red cells, and platelets.
The pattern of immunohistochemical staining depends on the localization of the antigen: nuclear, cytoplasmic, cytoplasmic and nuclear or membranous. 1 Phenotypic markers in major types of hematopoietic cells Target Marker/antibody Activated cells Anaplastic large cell lymphoma B-cell markers Blastic markers Germinal center cells Granulocytes Hairy cell leukemia Hematogones Hodgkin lymphoma, classical Immature T-cells/thymocytes Langerhans cells L&H cells (popcorn cells) Mast cells Megakaryocytes Monocytic markers Myeloid markers NK-cell markers Plasma cell markers Plasmacytoid dendritic cells Red blood cell precursors T-cell markers CD30, MUM1, CD138 ALK, CD30, pan-T antigens, CD43, UCHL1, EMA CD19, CD20, CD22, CD79a, Pax-5, Oct-2, BOB-1 CD34, CD117, CD1a, TdT CD10, bcl-6, B-cell markers CD10, CD11b, CD15, CD16, MPO CD25, CD103, B-cell markers, DBA44, annexin, TRAP, CD11c CD19, CD10, CD34, TdT CD30, CD15, Pax-5, MUM1 CD1a, CD4, CD8, TdT, pan-T antigens, CD10 CD1a, S100 B-cell markers, EMA, CD45 Mast cell tryptase, CD117, CD43, CD2 CD41, CD61, (CD79a) CD11b, CD11c, CD14, CD64, CD68, CD163, HLA-DR, CD4 CD13, CD15, CD33, CD68, MPO CD16, CD56, CD57 CD38, CD138, cytoplasmic light and heavy chains, CD56, CD117, MUM1 CD4, CD56 GPHA, hemoglobin A CD2, CD3, CD5, CD7, CD43, UCHL1 with CD45 (LCA).