By Alexander Sulakvelidze, Elizabeth Kutter
In line with the emergence of pathogenic micro organism that can't be taken care of with present antibiotics, many researchers are revisiting using bacteriophages, or phages, to struggle multidrug-resistant micro organism. Bacteriophages: Biology and functions presents unheard of, accomplished info on bacteriophages and their purposes, similar to phage remedy. It bargains innovations, media, and method interested by setting apart and dealing with healing phages. images, line drawings, and electron micrographs of phages also are incorporated. With its vast procedure, this booklet is an invaluable reference for microbiologists, hematologists, and infectious ailment researchers.
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Extra resources for Bacteriophages: Biology and Applications
Biochemical analysis of metabolic changes after phage infection gave some clues to how phage might grow and multiply inside infected cells. A particularly important theme in this research was the role of RNA in phage development. Quite early on, Volkin and Astrachan (1956) found that the RNA base composition in phage-infected cells was much more DNA-like than in uninfected cells. Soon thereafter, to explain the phenomena involved in induced enzyme synthesis in bacteria, Jacob and Monod (1961) hypothesized that an unstable RNA intermediate might provide the material link for information flow from the gene to the site of protein synthesis, the ribosome.
Electron micrograph provided by Dwight Anderson. with the host, as shown most clearly for coliphage T7 (Molineux, 2001). Archaea have their own set of infecting viruses, often called archaephages. Many of these have unusual, often pleiomorphic shapes that are unique to the Archaea, as discussed in Chapter 4. 8. The ten families of tailless phages described to date each have very few members. They are differentiated by shape (rods, spherical, lemon-shaped, or pleiomorphic); by whether they are enveloped in a lipid coat; by having double- or single-stranded DNA or RNA genomes, segmented or not; and by whether they are released by lysis of their host cell or are continually extruded from the cell surface.
Growing up in the phage group, in Phage and the Origins of Molecular Biology, J. S. D. ), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1966, pp. 239–245. D. , A structure for desoxyribose nucleic acids, Nature, 171, 737–738, 1953. , Recombinant DNA, Scientific American Books, New York, 1992. D. , Nucleic acid transfer from parent to progeny bacteriophage, Biochim Biophys Acta, 10, 432, 1953. , Molecular structure of deoxypentose nucleic acid, Nature, 171, 738–740, 1953. , Effect of radiations on bacteriophage C16, Nature, 145, 935, 1940.