Geriatrics

Download Bioactive Food as Dietary Interventions for the Aging by Ronald Ross Watson, Victor R. Preedy PDF

By Ronald Ross Watson, Victor R. Preedy

Bioactive nutrients as nutritional Interventions for the getting older Population presents medical proof of the influence bioactive meals could have within the prevention and mediation of age comparable illnesses. Written by way of specialists from all over the world, this quantity presents vital details that may not basically help in therapy treatments, yet motivate learn and new paintings concerning this area.

  • Focuses at the function of bioactive meals in addressing continual stipulations linked to getting older and senescence
  • Important details for constructing learn in this swiftly becoming inhabitants representing an more and more major monetary burden
  • Documents meals that could impact metabolic syndrome and methods the linked details should be used to appreciate different illnesses, which percentage universal etiological pathways.

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E. 1 Effects of Early Life Exposure to Soy or Soy Isoflavones on Bone Development Timing of Route of Reference Model exposure Studied until Treatment administration • DAI may promote fetal growth by increasing IGF-I receptor gene expression in skeletal muscle Conclusion: DAI influences fetal growth and this is associated with higher expression of IGF-I receptor gene in skeletal muscle and down-regulates the expression of the ER-b gene in the hypothalamus Neonatal exposure Julius et al. (1982) Piglet n ¼ 6/group Males, females PND 9–12 to PND 41–44 6 weeks Milk protein formulaa Soy protein isolate formulaa Oral • There was no difference in Continued Soy: Animal Studies, Spanning the Lifespan body weight or growth between pigs fed SPI and milk protein formula • Pigs fed SPI had lower plasma cholesterol compared to those exposed to milk protein formula • Bone calcium, measured as percent of dry, fat-free femur or whole carcass ash, was lower in pigs fed SPI compared to those fed milk protein formula Conclusion: Similar growth and development were observed in pigs fed SPI or MP formula; but pigs fed SPI formulas had significantly less bone calcium 387 388 Piekarz and Ward (2007) Mouse (CD-1) n ¼ 4–14/ group Males, females PND 1 to PND 5 16 weeks Chen et al.

Considering that isoflavones have estrogenic activity, it is hypothesized that they can induce the greatest biologic effects on bone when endogenous levels of sex steroids are low as occurs in early postnatal life and during aging. This chapter presents the scientific evidence from animal studies in which the effect of SPI and/or isoflavones on bone health have been investigated. Three distinct stages of the lifespan have been studied: early life, early adulthood, and aging. 2. ANIMAL MODELS USED FOR STUDYING EFFECTS OF SOY ON BONE METABOLISM The choice of animal model depends on the scientific question and the stage of the lifespan being investigated.

These studies provide a basis for investigating the effects of soy infant formula on bone development in humans and insight into potential mechanisms by which benefits may occur. Long-term follow-up of infants who consumed soy formula will provide a definitive answer on the potential of early life exposure to isoflavones on bone development and eventual adult bone health – such prospective trials are underway. 4. 2). For the most part, findings from these studies suggest small, if any, benefits to bone.

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