By Matt Kalaycio
Intriguing new "biologic" remedies for treating leukemia are showing so swiftly that clinicians usually locate it tough to make trained judgements approximately their use while making sufferer remedy judgements. Biologic remedy of Leukemia summarizes and stories all of the on hand info bearing on those state-of-the-art biologic remedies in order that training clinicians could make the right kind patient-care offerings. the following the busy health professional will locate in a single handy position an important details at the makes use of and barriers of the foremost biologic remedies for leukemia, the various biologic innovations for its therapy, the administration of sufferers being taken care of with such biologic brokers, and the present and destiny position of rising biologic brokers.
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Extra resources for Biologic Therapy of Leukemia (Contemporary Hematology)
However, rituximab is less effective in clearing the bone marrow of malignant cells and in reducing the size of enlarged lymph nodes. As a result, remissions are usually short lived. The relatively modest benefit of rituximab in previously treated B-CLL and the intriguing activity noted in the six untreated patients in Byrd’s study (29) 34 Kalaycio suggest a potential role for rituximab earlier in the natural history of the disease. Furthermore, rituximab’s excellent tolerability profile makes it an ideal agent with which to investigate combination therapies.
Theoretically, if one accepts the hypothesis that the GVL effect operates through mechanisms other than simple alloantigen recognition, one might decrease the morbidity and mortality of GVHD if a state of immune tolerance could be obtained. Therefore, if both donor and recipient cells are present in a given host, without clinical GVHD, then a state of immune tolerance would theoretically exist and hopefully the donor cells might still be able to generate a GVL effect. This situation has been described clinically and is known as mixed hematopoietic chimerism.
Ann Int Med 1988;108:806–814. 21. Marmont A, Horowitz M, Gale R, et al. T-cell depletion of HLA-identical transplants in leukemia. Blood 1991;78:2120–2130. 22. Champlin R, Ho W, Gajewski J, et al. Selective depletion of CD8+ T lymphocytes for prevention of graft-versus-host disease after allogeneic bone marrow transplantation. Blood 1990;76:418–423. Chapter 2 / Graft vs Leukemia Effect 25 23. Champlin R, Jansen J, Ho W, et al. Retention of graft-versus-leukemia using selective depletion of CD8-positive T lymphocytes for prevention of graft-versus-host disease following bone marrow transplantation for chronic myelogenous leukemia.