Hematology

Download Cell Membrane: The Red Blood Cell as a Model by Yoshihito Yawata PDF

By Yoshihito Yawata

This ebook offers the constitution and serve as of organic membranes to enhance the knowledge of cells in either general and pathogenic states. lately, sizeable quantities of latest details were amassed, particularly approximately pathological stipulations, and there's now a lot facts correlating genotypes and phenotypes in common and ailment states. This e-book surveys the newest findings in examine at the molecular biology, biochemistry, and genetics of the membranes of human crimson blood cells.

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140: 210À226. Castle, W. , Daland, G. A. (1937) Susceptibility of erythrocytes to hypotonic hemolysis as a function of dis- 11 12 13 14 15 16 17 18 19 20 coidal form. Am. J. Physiol. 120: 371À383. Ham, T. , Castle, W. B. (1940) Studies on destruction of red blood cells. Relation of increased hypotonic fragility and of erythrostasis to the mechanism of hemolysis in certain anemias. Proc. Am. Phil. Soc. 82: 411À419. Ponder, E. (1948) Hemolysis and Related Phenomena. Grune and Stratton, New York. Dacie, J.

MAPs are equivalent to intramembrane particles (IMPs), 80 % of which are composed of band 3 molecules. In the early 1970s, when electron microscopy with the freeze-fracture method became widely utilized, MAPs, that is IMPs, appeared to be considered erroneously as glycophorins, which were being investigated extensively at that time [77]. In normal subjects, IMPs (mostly band 3 molecules) are distributed regularly like icebergs floating on the sea with wide open channels of water between them (Fig.

In red cell membranes of various species of mammals, the asymmetry of the distribution of these phospholipids has been observed as being a fairly common phenomenon. The extent of this asymmetry, however, is variable, that is, PC at the outer leaflet of pig’s platelets is about 40 % of the total PC, and only 20 % of the total PC is present at the brushborder of a rabbit’s gut [6]. The biological significance of the variation of phospholipid distribution among the various species of mammals is not known at the present time.

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