Hematology

Download Chronic Lymphocytic Leukemia by Federico Caligaris-Cappio, Riccardo Dalla Favera PDF

By Federico Caligaris-Cappio, Riccardo Dalla Favera

Chronic lymphocytic leukaemia (CLL) is the commonest leukaemia within the Western global. it's also the prototype of B-cell persistent lymphoid malignancies and in their ramifications in the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now turn into the point of interest of significant curiosity and progressively more investigators from various parts, together with genetics, molecular biology, easy and utilized immunology have gotten actively engaged within the research of CLL. Clinicians are contemplating CLL as a really attention-grabbing aim of many initiatives which objective at translating the hot and intriguing advancements of uncomplicated technological know-how into powerful new ways to the sufferer.

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37 5 B-CLL Pathogenesis . . . . . . . . . . . . . . . . . . . 41 6 Summary and Conclusions . . . . . . . . . . . . . . . . . 43 References . . . . . . . . . . . . . . . . . . . . . . . . . 44 Abstract For many decades, B cell chronic lymphocytic leukemia (B-CLL) stood out as a B cell-derived malignancy that was difficult to position within the framework of the available B cell differentiation scheme: First, the histology as well as the immunophenotype did not quite resemble that of any normal lymphocyte; second, in contrast to almost all other B cell tumor subtypes, the immunoglobulin variable region (IgV) genes of B-CLL cases could be either unmutated or somatically mutated; third, the genomic lesions observed in B-CLL were markedly distinct from those of the other major B cell malignancies, which typically exhibit balanced chromosome translocations.

43 References . . . . . . . . . . . . . . . . . . . . . . . . . 44 Abstract For many decades, B cell chronic lymphocytic leukemia (B-CLL) stood out as a B cell-derived malignancy that was difficult to position within the framework of the available B cell differentiation scheme: First, the histology as well as the immunophenotype did not quite resemble that of any normal lymphocyte; second, in contrast to almost all other B cell tumor subtypes, the immunoglobulin variable region (IgV) genes of B-CLL cases could be either unmutated or somatically mutated; third, the genomic lesions observed in B-CLL were markedly distinct from those of the other major B cell malignancies, which typically exhibit balanced chromosome translocations.

Int J Cancer 91:474–480 Taylor BJ, Pittman JA, Seeberger K, Mant MJ, Reiman T, Belch AR, Pilarski LM (2002) Intraclonal homogeneity of clonotypic immunoglobulin M and diversity of nonclinical post-switch isotypes in multiple myeloma: insights into the evolution of the myeloma clone. Clin Cancer Res 8:502–513 Tiwari S, Felekkis K, Moon EY, Flies A, Sherr DH, Lerner A (2004) Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis.

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