By Craig S. Kitchens MD, Barbara A Konkle MD, Craig M. Kessler MD
2014 BMA clinical e-book Awards hugely recommended in inner drugs classification!
A unique medical focus makes Consultative Hemostasis and Thrombosis, third Edition your go-to advisor for speedy, sensible solutions on dealing with the complete diversity of bleeding and clotting problems. Emphasizing real-world difficulties and suggestions, Dr. Craig S. Kitchens, Dr. Barbara A. Konkle, and Dr. Craig M. Kessler offer all the medical counsel you need to make optimum judgements on behalf of your sufferers and advertise the absolute best outcomes.
- Efficiently search for concise descriptions of every condition, its linked indicators, laboratory findings, analysis, differential prognosis, and treatment.
- Get the newest information
- Apply today’s latest therapies, together with those who are speedy turning into ordinary during this fast-changing field.
- Meet the wishes of particular sufferer groups with a brand new bankruptcy on Bleeding and the administration of Hemorrhagic problems in Pregnancy and an generally up to date bankruptcy on Thrombosis and Cancer.
- Zero in on key information with a brand new simple layout, and all-new full-color format, ample laboratory protocols, and at-a-glance tables and charts throughout.
- Access the whole textual content and illustrations online - absolutely searchable - at www.expertconsult.com.
on scorching subject matters similar to Disseminated Intravascular Coagulation, Thrombophilia, medical and Laboratory review and administration, Thrombotic -Thrombocytopenic Purpura, and Heparin-Induced Thrombocytopenia.
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Additional resources for Consultative Hemostasis and Thrombosis. Expert Consult - Online and Print
On the procoagulant side, endothelial cells synthesize PAI-1, von Willebrand factor (VWF), protease activated receptors, and rarely TF. On the anticoagulant side, endothelial cells express, synthesize, and/or release TFPI, TM, EPCR, tissue-type plasminogen activator (tPA) and heparan. However, these factors are not expressed uniformly throughout the vasculature. 39 The picture that emerges is one of heterogeneity layered upon heterogeneity. Indeed, if one were to survey endothelial cells from different sites of the vasculature, one would find that they mediate hemostasis via site-specific “formulas” of procoagulants and anticoagulants (Fig.
Kelly KA, Allport JR, Tsourkas A, et al: Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle. Circ Res 96:327–336, 2005. 41 53. Fichtlscherer S, Zeiher AM, Dimmeler S: Circulating microRNAs: biomarkers or mediators of cardiovascular diseases? Arterioscler Thromb Vasc Biol 31:2383–2390, 2011. 54. Walter DH, Dimmeler S, Zeiher AM: Effects of statins on endothelium and endothelial progenitor cell recruitment. Semin Vasc Med 4:385– 393, 2004. 55. Pardridge WM: The blood-brain barrier: bottleneck in brain drug development.
One mechanism underlying this site specificity is the preferential expression of E-selectin, P-selectin, vascular cell adhesion molecule (VCAM)-1 and ICAM-1 in the endothelium of postcapillary venules. Under certain conditions, leukocyte trafficking may occur in other segments of the vascular tree, including large veins, arterioles, and capillaries. 29 In addition to regulating leukocyte transfer, the endothelium plays other roles in the innate immune response. For example, activated endo- thelial cells may express and/or release a multitude of inflammatory mediators.