By Balwinder, M.D. Singh
Disseminated intravascular coagulation is a devastating syndrome characterized by way of the systemic activation of frequent activation of the coagulation cascade and thrombosis, that could lead to critical bleeding and should bring about organ failure. fresh reviews have proven that the occurrence of DIC is lowering, specifically in males. regardless of the advancements in healthiness care supply, the morbidity and mortality because of DIC is still very excessive. This booklet presents an immense well timed replace at the scientific manifestations, very important possibility elements, and therapy concepts for DIC, and offers in-depth info on pathophysiological facets and diverse diagnostic rankings used to diagnose DIC.
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Extra resources for Disseminated Intravascular Coagulation (DIC): Clinical Manifestations, Diagnosis and Treatment Options
Aortic aneurysm-induced disseminated intravascular coagulation. Ann Vasc Surg 1996;10:396-405.. , Jr Purification, characterization, and fibrinogen cleavage sites of three fibrinolytic enzymes from the venom of Crotalus basiliscus basiliscus. Biochemistry. 1992;31:4547–4557.  Retzios AD, Markland FS. Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basiliscus basiliscus: cleavage site specificity towards the alpha-chain of fibrin. Thromb Res. 1994;74:355–367  Singletary EM, Rochman AS, Bodmer JC, Holstege CP.
Pregnancy in itself, due to various physiological changes is a hypercoagulable state predisposing women to varying severity of DIC ranging from a less severe thrombotic form to a full blown one. The incidence of DIC with in the obstetric population is extremely variable depending upon the suspected underlying cause. Before discussing further, it‘s apt at this juncture to discuss the physiological changes which make a parturient hypercoagulable and therefore prone to DIC. Most of these changes are usually hormone driven.
Thrombomodulin and Disseminated Intravascular Coagulation 47 TM may also attenuate inflammation by binding and neutralizing lipopolysaccharide (LPS). TMD1 domain specifically binds to Lewis Y antigen in LPS of gram-negative bacteria . LPS, a component of the cell wall of gram-negative bacteria, provides a potent signal to the innate immune system and is often used to model gram-negative infections in vitro and in vivo. LPS interacts with CD14 and toll-like receptor on the cell surface and transduces signals from the cell membrane into the cytosol, activating the downstream pro-inflammatory signaling pathways .